Inhibition of 2′3′-Cyclic GMP-AMP (cGAMP)-induced activation of interferon regulatory factor (IRF) by a novel compound
Abstract
We found COB-214 downregulates cGAMP-induced CXCL10 (a key chemokine) production and inhibits IRF activation in THP-1 cells. Our findings suggest that COB-214 has potential as an anti-inflammatory therapeutic that has selectivity for the IRF pathway.
Keywords:
IRF, NF-kB, COB-214, 2'3'-cGAMP, Chemical and Biomolecular Engineering
Status
Graduate
Department
Chemical and Biomolecular Engineering
College
Russ College of Engineering and Technology
Campus
Athens
Faculty Mentor
Goetz, Douglas
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.
Inhibition of 2′3′-Cyclic GMP-AMP (cGAMP)-induced activation of interferon regulatory factor (IRF) by a novel compound
We found COB-214 downregulates cGAMP-induced CXCL10 (a key chemokine) production and inhibits IRF activation in THP-1 cells. Our findings suggest that COB-214 has potential as an anti-inflammatory therapeutic that has selectivity for the IRF pathway.