Effect of high glucose on inflammatory functions of RAW 264.7 murine macrophages in vitro

Presenter Information

Grace Matocha

Abstract

In diabetes, macrophages infiltrate islets and have a pathogenic role on β-cells destruction through the sustained production of proinflammatory cytokines such as TNF-α, IL-6 and IL-1β. Macrophages trigger an inflammatory response.

Keywords:

Glucose, macrophages, inflammatory function, collagen, type 1 diabetes

Status

Undergraduate

Department

Biological Sciences

College

College of Arts and Sciences

Campus

Athens

Faculty Mentor

Benencia, Fabian

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Effect of high glucose on inflammatory functions of RAW 264.7 murine macrophages in vitro

In diabetes, macrophages infiltrate islets and have a pathogenic role on β-cells destruction through the sustained production of proinflammatory cytokines such as TNF-α, IL-6 and IL-1β. Macrophages trigger an inflammatory response.