T-Box Riboswitch Modulators as Novel Antibacterial Agents
Author ORCID
Abstract
The T-box riboswitch has been sourced as a viable drug target in combating diseases caused by gram positive bacteria by developing novel molecules that can act as an inhibitor by binding to any accessible druggable pocket specifically the antiterminator within the T-box, and influence its structural conformation preventing the cognate tRNA from being recognized by the anticodon and hence inhibiting gene expression and synthesis of protein monomers, thereby preventing gram-positve bacterial infections.
Status
Graduate
Department
Chemistry & Biochemistry
College
College of Arts and Sciences
Campus
Athens
Faculty Mentor
Bergmeier, Stephen C.
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.
T-Box Riboswitch Modulators as Novel Antibacterial Agents
The T-box riboswitch has been sourced as a viable drug target in combating diseases caused by gram positive bacteria by developing novel molecules that can act as an inhibitor by binding to any accessible druggable pocket specifically the antiterminator within the T-box, and influence its structural conformation preventing the cognate tRNA from being recognized by the anticodon and hence inhibiting gene expression and synthesis of protein monomers, thereby preventing gram-positve bacterial infections.