Rescuing brain endothelial cell function through pharmacological inhibition of Adrenomedullin signaling
Abstract
Brain arteriovenous malformation (AVM) is a neurovascular disorder characterized by abnormal endothelial cell function and overall blood vessel dysfunction, which we have previously observed using in vitro and in vivo models, and this study aims to investigate whether inhibiting Adrenomedullin signaling can prevent cytoskeletal anomalies, restore endothelial function, and promote neurovascular health in our in vitro system.
Status
Graduate
Department
Biological Sciences
College
College of Arts and Sciences
Campus
Athens
Faculty Mentor
Nielsen, Corinne
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.
Rescuing brain endothelial cell function through pharmacological inhibition of Adrenomedullin signaling
Brain arteriovenous malformation (AVM) is a neurovascular disorder characterized by abnormal endothelial cell function and overall blood vessel dysfunction, which we have previously observed using in vitro and in vivo models, and this study aims to investigate whether inhibiting Adrenomedullin signaling can prevent cytoskeletal anomalies, restore endothelial function, and promote neurovascular health in our in vitro system.