Effect of an IRF3 inhibitor on ovarian cancer cells

Presenter Information

Shuhd Al Noumani

Abstract

In these studies, we investigated the effect of phenylmethimazole (C10), an IRF3 inhibitor, on the proliferative capability of ovarian cancer cells, and on their behavior in wound healing assays. In addition, we investigated the expression of inhibitor molecules CD47 and PDL1 on these cells. Although the treatment was not able to significantly affect proliferation, we observed a decrease in the capability of these cells to timely close the gaps generated in the context of wound healing assays. Further studies will investigate the overall response of these cells to phenylmethimazole to evaluate its anticancer potential for ovarian cancer.

Status

Graduate

Department

Chemical and Biomolecular Engineering

College

Russ College of Engineering and Technology

Campus

Athens

Faculty Mentor

Benencia , Fabian

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Effect of an IRF3 inhibitor on ovarian cancer cells

In these studies, we investigated the effect of phenylmethimazole (C10), an IRF3 inhibitor, on the proliferative capability of ovarian cancer cells, and on their behavior in wound healing assays. In addition, we investigated the expression of inhibitor molecules CD47 and PDL1 on these cells. Although the treatment was not able to significantly affect proliferation, we observed a decrease in the capability of these cells to timely close the gaps generated in the context of wound healing assays. Further studies will investigate the overall response of these cells to phenylmethimazole to evaluate its anticancer potential for ovarian cancer.