Nucleobase protonation in an RNA Thermometer
Author ORCID
Abstract
This study investigates the pH-dependent behavior of the shuT RNA thermometer in Shigella dysenteriae, revealing a protonation event and an upward pKa shift, which may influence RNA stability, function, and potential RNA-targeted drug design.
Status
Graduate
Department
Chemistry & Biochemistry
College
College of Arts and Sciences
Campus
Athens
Faculty Mentor
Hines, Jennifer
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.
COinS
Nucleobase protonation in an RNA Thermometer
This study investigates the pH-dependent behavior of the shuT RNA thermometer in Shigella dysenteriae, revealing a protonation event and an upward pKa shift, which may influence RNA stability, function, and potential RNA-targeted drug design.