Nucleobase protonation in an RNA Thermometer

Presenter Information

Opeyemi Fatunbi

Author ORCID

0009-0003-6205-0230

Abstract

This study investigates the pH-dependent behavior of the shuT RNA thermometer in Shigella dysenteriae, revealing a protonation event and an upward pKa shift, which may influence RNA stability, function, and potential RNA-targeted drug design.

Status

Graduate

Department

Chemistry & Biochemistry

College

College of Arts and Sciences

Campus

Athens

Faculty Mentor

Hines, Jennifer

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Nucleobase protonation in an RNA Thermometer

This study investigates the pH-dependent behavior of the shuT RNA thermometer in Shigella dysenteriae, revealing a protonation event and an upward pKa shift, which may influence RNA stability, function, and potential RNA-targeted drug design.