RNA Protonation: A Pathway to Drug Discovery.
Abstract
The protonation of nucleobases plays a vital role in RNA structure and function. Measuring the pH dependence of viral RNAs conserved elements like the stem-loop II motif in SARS-CoV and SARS-CoV-2 offers a promising route for discovering antiviral drugs, highlighting its potential as a drug target.
Keywords:
Infectious Diseases, RNA pH dependence, Stem-loop II motif (s2m), SARS-CoV and SARS-CoV-2, and Antiviral drug discovery
Status
Graduate
Department
Chemistry & Biochemistry
College
College of Arts and Sciences
Campus
Athens
Faculty Mentor
Hines, Jennifer
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.
RNA Protonation: A Pathway to Drug Discovery.
The protonation of nucleobases plays a vital role in RNA structure and function. Measuring the pH dependence of viral RNAs conserved elements like the stem-loop II motif in SARS-CoV and SARS-CoV-2 offers a promising route for discovering antiviral drugs, highlighting its potential as a drug target.