Design and recognition of cucurbituril-secured platinum-bound oligopeptides
Platinum terpyridyl complexes, stacked on top of one another and secured as dimers with cucurbituril (CB) in aqueous medium, were functionalized quantitatively andin situwith a pair of pentapeptides Phe-(Gly)3-Cys by grafting their cysteine residues to the Pt centers. The resulting CB·(Pt·peptide)2assemblies were used to target secondary hosts CB and CBviatheir pair of phenylalanine residues, againin situ. A series of well-defined architectures, including a supramolecular “pendant necklace” with hybrid head-to-head and head-to-tail arrangements inside CB, were obtained during the self-sorting process after combining only 3 or 4 simple building units.
Barbero, Héctor and Masson, Eric, "Design and recognition of cucurbituril-secured platinum-bound oligopeptides" (2021). Chemistry & Biochemistry Open Access Publications. 33.