Highly Efficient and Stereoselective Thioallylation of Alkynes: Possible Gold Redox Catalysis with No Need for a Strong Oxidant
© 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim Stereoselective thioallylation of alkynes under possible gold redox catalysis was accomplished with high efficiency (as low as 0.1 % catalyst loading, up to 99 % yield) and broad substrate scope (various alkynes, inter- and intramolecular fashion). The gold(I) catalyst acts as both a π-acid for alkyne activation and a redox catalyst for AuI/III coupling, whereas the sulfonium cation generated in situ functions as a mild oxidant. This novel methodology provides an exciting system for gold redox catalysis without the need for a strong oxidant.
Wang, Jin; Zhang, Shuyao; Xu, Chang; Wojtas, Lukasz; Akhmedov, Novruz G.; Chen, Hao; and Shi, Xiaodong, "Highly Efficient and Stereoselective Thioallylation of Alkynes: Possible Gold Redox Catalysis with No Need for a Strong Oxidant" (2018). Chemistry & Biochemistry Open Access Publications. 25.