Title
Lessons from growth hormone receptor gene-disrupted mice: Are there benefits of endocrine defects?
Document Type
Article
Publication Date
5-1-2018
Abstract
© 2018 European Society of Endocrinology Printed in Great Britain. Growth hormone (GH) is produced primarily by anterior pituitary somatotroph cells. Numerous acute human (h) GH treatment and long-term follow-up studies and extensive use of animal models of GH action have shaped the body of GH research over the past 70 years. Work on the GH receptor (R)-knockout (GHRKO) mice and results of studies on GH-resistant Laron Syndrome (LS) patients have helped define many physiological actions of GH including those dealing with metabolism, obesity, cancer, diabetes, cognition and aging/longevity. In this review, we have discussed several issues dealing with these biological effects of GH and attempt to answer the question of whether decreased GH action may be beneficial.
Recommended Citation
Basu, Reetobrata; Qian, Yanrong; and Kopchick, John J., "Lessons from growth hormone receptor gene-disrupted mice: Are there benefits of endocrine defects?" (2018). Biomedical Sciences Open Access Publications. 7.
https://ohioopen.library.ohio.edu/biomedical-oapub/7