New insights of growth hormone (GH) actions from tissue-specific GH receptor knockouts in mice
© AE & M all rights reserved. In order to provide new insights into the various activities of GH in specific tissues, recent advances have allowed for the generation of tissue-specific GHR knockout mice. To date, 21 distinct tissue-specific mouse lines have been created and reported in 28 publications. Targeted tissues include liver, muscle, fat, brain, bone, heart, intestine, macrophage, pancreatic beta cells, hematopoietic stem cells, and multi-tissue “global”. In this review, we provide a brief history and description of the 21 tissue-specific GHR knockout mouse lines.
List, Edward O.; Berryman, Darlene E.; Jensen, Elizabeth A.; Kulkarni, Prateek; McKenna, Savannah; and Kopchick, John J., "New insights of growth hormone (GH) actions from tissue-specific GH receptor knockouts in mice" (2019). Biomedical Sciences Open Access Publications. 54.