Phase-Variable Genotypes Sweetened by Glycosylation Phenotypes
© 2018 American Society for Microbiology. The affordability of bacterial genome sequencing has provided a helpful tool for sequencing large strain collections. Bente Børud (J. Bacteriol. 200:e00794-17, 2018, https://doi.org/doi:10.1128/JB.00794-17) recently led an effort to analyze the genomes of a collection of oropharyngeal Neisseria meningitidis isolates from 50 healthy individuals. Paired longitudinal isolates from each individual were sequenced. Genome analyses focused on (i) predicting the expression state of phase-variable loci that encode enzymes important for O-linked protein glycosylation and (ii) correlating specific genotypes with glycosylation phenotypes.
Weyand, Nathan J., "Phase-Variable Genotypes Sweetened by Glycosylation Phenotypes" (2018). Biological Sciences Open Access Publications. 62.